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Musings on my Acquisition of an iPod Nano

Sunday, 26 October 2008 2:00 A GMT-06

Greyhound scraps ads after Canada bus beheading

Wednesday, 6 August 2008 3:27 P GMT-06

Obama says McCain campaign cynical, not racist

Sunday, 3 August 2008 1:43 A GMT-06

Exercise in a pill? Researchers find two - Yahoo! News

Friday, 1 August 2008 12:57 P GMT-06

Spitzer linked to prostitute ring | Video | Reuters.com

Tuesday, 11 March 2008 7:15 A GMT-06

Network Solutions steals domain ideas; Confirmed!

Tuesday, 26 February 2008 2:27 A GMT-06

Evidence Eraser Software Review

Saturday, 26 January 2008 3:26 P GMT-06

SURREAL Network Social Network Launched

Thursday, 3 January 2008 9:45 P GMT-06

The Famous Magic Pie vs. KFC's Famous Bowl

Friday, 12 October 2007 7:11 P GMT-06

When Did Halloween Change?

Sunday, 30 September 2007 1:44 P GMT-06

Tenacious D - Papagenu (he's my sassafrass)

Saturday, 29 September 2007 7:56 P GMT-06

Spare the Rod, Spoil the Monkey

Saturday, 29 September 2007 1:45 P GMT-06

I Only Want to See You Drinking in the "Chocolate Rain"

Friday, 17 August 2007 1:04 P GMT-06
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Film: Another Spec Ad from Meredith Scardino and Dave Hill

Monday, 21 May 2007 7:18 P GMT-06
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La Pared del Bebé

Saturday, 5 May 2007 9:21 P GMT-06

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Latest Entries

Musings on my Acquisition of an iPod Nano

Sunday, 26 October 2008 2:00 A GMT-06
I finally broke down and bought an iPod Nano.  Now I've entered the world of digital downloads.  I resisted for so long because I fancied myself as a quasi-luddite, who preached the virtues of the good 'ole vinyl album (and later th

SURREALestate.com Offering Parcels of the Collective Unconscious Amid Controversy

Thursday, 4 September 2008 2:04 P GMT-06
<!-- Body --> SURREALestate.com, and organization that has proclaimed itself the official registrar of the collective unconscious is offering parcels of the

Aquatic Symbolism and Roman Mythological References in "Leave it to Beaver": An Evolutionary Analog

Thursday, 4 September 2008 1:26 P GMT-06
What's in a (Sur)name?I just watched an rerun episode of the old sitcom Leave it to Beaver (1957-63) on TV Land. The aquatic symbolism and Roman mythological references are obvious. Before we get to those, we have to set the foundation. The famil

Greyhound scraps ads after Canada bus beheading

Wednesday, 6 August 2008 3:27 P GMT-06
Greyhound scraps ads after Canada bus beheading

By ROB GILLIES, Associated Press Writer
Wednesday, August 6, 2008

Quoting from this site:(08-06) 13:28 PDT TORONTO, Canada (AP) --Greyhound has scrapped an ad campaign that extolled the relaxing

Rapid Alzheimer's Improvement After New Immune-based Treatment

Sunday, 3 August 2008 2:58 A GMT-06
Quoting from Science Daily:Rapid Alzheimer's Improvement After New Immune-based TreatmentScienceDaily (July 21, 2008)

— New research into the treatment of Alzheimer's disease reports improvement in language abilities using a novel immune-bas

Exercise in a pill? Researchers find two - Yahoo! News

posted Friday, 1 August 2008
y Maggie Fox, Health and Science Editor Thu Jul 31, 12:17 PM ET

WASHINGTON (Reuters) - Researchers who genetically engineered "marathon mice" that could run for hours have found two pills that can mimic the effects -- and they have already developed a test for the drugs in case athletes try to cheat with them.









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The drugs reproduce many of the biological benefits of exercise, helping cells burn fat better and boosting endurance, said Ronald Evans, a Howard Hughes Medical Institute researcher at the Salk Institute for Biological Studies in California.


One of the pills may some day help people enhance their exercise or training, while the other might be more suited for couch potatoes who need to kick-start themselves, Evans and colleagues reported on Thursday in the journal Cell.


"If you like exercise, you like the idea of getting more bang for your buck," Evans said in a statement. "If you don't like exercise, you love the idea of getting the benefits from a pill."


In 2004, Evans and his colleagues genetically engineered mice by tweaking a gene called PPAR-delta, a master regulator of different genes. Gene-engineered mice could run twice as far as normal mice and stayed lean even when fed a high-fat diet.


The next step was to find a drug that might mimic these effects.


Evans tested a compound called GW1516, one of a family of compounds that researchers are looking at as obesity and diabetes drugs. But even though it affected the genes of the mice, it did not affect their metabolism.


"There was no change at all in running performance. Nothing -- not even a percent," Evans said in a statement.


MIMICKING LIFE


Then the researchers thought about what happens in real life.


"If you're out of shape -- and most of us are -- and you want to change, you have to do some exercise. The way we reprogram muscle in adults is by training."


So they trained the mice while some were on the drug and others were not.


All the mice became more athletic but those given GW1516 ran 68 percent longer than those that had only done the exercise training. "The dramatic effect of the drug was stunning," Evans said.


But that does not help people who might have muscle-wasting diseases, fatigue, or who are too overweight to exercise.


They went back to see if there was a different way to affect PPAR-delta. One compound that is well understood already is AMP-activate protein kinase or AMPK, "a master regulator of cellular and organismal metabolism," they wrote.


"We think AMPK activity is the secret to allowing PPAR-delta drugs to work," Evans said.


A drug called AICAR mimics AMP, Evans said, "so muscle thinks it's burning fat."


Mice given AICAR ran 44 percent longer than untreated animals, the researchers found.


"This is a drug that is like pharmacological exercise," Evans says. "After four weeks of receiving the drug, the mice were behaving as if they'd been exercised."


Treated mice could outrun mice given traditional exercise training, Evans said.


"Almost no one gets the recommended 40 minutes to an hour per day of exercise," Evans said. "For this group of people, if there was a way to mimic exercise, it would make the quality of exercise that they do much more efficient."


The pills are only available experimentally now and Evans is not working with any drug company. But GW1516 has a relatively simple chemical structure and can be synthesized easily, Evans said.


His team created a mass spectrometry test to detect the two drugs and their metabolic by-products in the blood or urine. They are working with the World Anti-Doping Agency to develop the test, perhaps in time to retroactively test 2008 Olympic athletes.


(Editing by Julie Steenhuysen and Philip Barbara)




Quoting from Yahoo! News


 

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